Table 5.

Average tolerability scores of subjects across groups.

Outcome Measurement	Group 1 1 Stick		Group 2 2 Sticks		Group 3 3 Sticks		Group 4 Placebo
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Bloating
Visit 1	2.72	2.61	0.65	0.83	1.31	1.00	0.96	0.68
Visit 2	1.25	1.68	1.71	2.13	1.82	1.93	0.77	0.73
Visit 3	1.46	1.76	2.49	3.05	1.90	1.28	0.53	0.58
Constipation
Visit 1	0.48	0.69	0.11	0.23	0.62	1.12	0.48	0.40
Visit 2	0.17	0.27	0.18	0.41	0.38	0.80	0.44	0.33
Visit 3	0.31	0.47	0.77	1.63	0.61	1.21	0.22	0.21
Diarrhea
Visit 1	0.00	0.00	0.26	0.66	0.01	0.04	0.43	0.68
Visit 2	0.14	0.42	0.27	0.49	0.25	0.49	1.13	2.50
Visit 3	0.46	0.71	0.49	0.85	0.31	0.56	0.82	1.48
Frequent Urination
Visit 1	1.66	2.08	0.77	0.89	2.08	2.64	1.41	1.63
Visit 2	2.16	2.03	2.13	2.13	3.79	2.24	1.93	1.72
Visit 3	1.64	1.24	2.23	2.60	2.99	2.65	1.54	1.50
Gas
Visit 1	0.91	1.23	1.26	1.52	1.36	1.05	0.95	0.85
Visit 2	1.16	1.23	1.91	1.85	1.77	1.46	1.12	1.12
Visit 3	1.00	1.44	1.96	2.51	1.71	1.36	0.73	0.75
Nausea
Visit 1	0.48	1.09	0.03	0.08	0.32	0.73	0.26	0.40
Visit 2	0.41	0.60	0.19	0.43	0.24	0.41	0.65	1.28
Visit 3	0.01	0.04	0.56	0.72	0.39	0.53	0.22	0.37
Stomach Fullness
Visit 1	2.37	2.04	2.52	2.43	2.38	2.30	1.88	2.06
Visit 2	1.77	2.19	2.53	2.46	3.50	2.46	0.58	0.65
Visit 3	1.65	2.22	3.08	2.60	2.86	2.12	0.67	0.85
Abdominal Cramping
Visit 1	0.29	0.77	0.11	0.15	0.32	0.52	0.16	0.24
Visit 2	0.08	0.21	0.22	0.52	0.98	1.23	0.16	0.24
Visit 3	0.12	0.37	1.42	2.19	0.47	0.84	0.26	0.42
Total Tolerability Score
Visit 1	8.46	7.23	5.71	5.12	8.40	5.21	6.53	4.20
Visit 2	7.13	5.05	9.12	8.45	12.73	7.63	6.78	4.77
Visit 3	6.65	5.60	13.26	14.04	11.23	5.72	4.99	3.94

Total tolerability score, bloating, abdominal cramping; interactions = significant interactions between treatment and time (p = 0.044, 0.039, and 0.010, respectively); frequent urination = visit 1 and 2 differ with time.