Figure 1.

Illustration of ADT and IADT separately (Created with BioRender.com). The three panels, labeled (A), (B) and (C), depict green cells as responsive cancer cells and red cells as resistant cancer cells. In the lowest panel C), we illustrate the tumor lesion of prostate cancer. In A), continuous dosing kills responsive cancer cells, but the resistant cancer cells quickly dominate the population due to the lack of competition from responsive cells. In contrast, B) shows that intermittent dosing allows responsive cancer cells to regrow during therapy-free periods. This enables them to compete more effectively, resulting in the resistant cells being unable to dominate the entire population even in the late stages of treatment.