Table 2.
Prenatal Iodine intake and maternal pregnancy mental health symptoms scores.
| Prenatal Anhedonia Symptoms | Prenatal Global EPDS Score | |||
|---|---|---|---|---|
| Odds Ratio (95% CI) | Odds Ratio (95% CI) | |||
| Dietary Iodine Intake | Crude | Adjusted | Crude | Adjusted |
| <100 µg/day | 1.03 (0.61, 1.73) | 0.99 (0.58, 1.67) | 0.87 (0.52, 1.47) | 0.82 (0.48, 1.40) |
| 100–<160 µg/day | 1.14 (0.71, 1.84) | 1.17 (0.72, 1.90) | 0.97 (0.60, 1.57) | 0.96 (0.59, 1.57) |
| 160–220 µg/day | Ref. | Ref. | Ref. | Ref. |
| >220–<400 µg/day | 1.05 (0.63, 1.75) | 1.04 (0.62, 1.74) | 1.13 (0.68, 1.86) | 1.09 (0.65, 1.83) |
| ≥400 µg/day | 1.40 (0.80, 2.47) | 1.29 (0.72, 2.30) | 1.35 (0.77, 2.36) | 1.16 (0.65, 2.08) |
| Dietary and supplemental iodine | ||||
| <100 µg/day | 0.98 (0.58, 1.67) | 0.96 (0.56, 1.65) | 0.89 (0.52, 1.53) | 0.86 (0.49, 1.50) |
| 100–<160 µg/day | 1.00 (0.62, 1.65) | 1.04 (0.63, 1.71) | 0.93 (0.56, 1.53) | 0.93 (0.56, 1.56) |
| 160–220 µg/day | Ref. | Ref. | Ref. | Ref. |
| >220–<400 µg/day | 0.97 (0.60, 1.58) | 0.97 (0.59, 1.60) | 1.08 (0.66, 1.76) | 1.07 (0.65, 1.77) |
| ≥400 µg/day | 1.19 (0.69, 2.05) | 1.12 (0.64, 1.94) | 1.33 (0.78, 2.29) | 1.18 (0.68, 2.06) |
Models were adjusted for child sex, maternal age at birth, maternal race/ethnicity, education, pre-pregnancy depression, parity, and previous treatment for a thyroid disease. Anhedonia was based on items 1 and 2 of the 10-item EPDS (Edinburg depression scale), and those with a score of ≥1 were categorized with anhedonia symptoms and 0 with no anhedonia symptoms. Global depressive symptoms were based on a score ≥ 10 on the 10-item EPDS depression scale. Reference for iodine intake was based on the IOM, EAR (160 µg/day), and RDA (220 µg/day) for pregnant women in the US.