| Study | Comparison | NYHA class* | Outcome |
|---|---|---|---|
| V-HeFT I | Hydralazine plus isosorbide dinitrate v placebo | II, III | Improved mortality with active treatment |
| V-HeFT II | Hydralazine plus isosorbide dinitrate v enalapril | II, III | Enalapril superior to hydralazine plus isosorbide dinitrate for survival |