Table 2.

Sensitivity and Specificity of sNfL Elevations Above the 95th Percentile Thresholds

	Gd+ lesion occurrence
	Gd+	No Gd+
Peak sNfL
Above 19.6 pg/mL	17	8	PPV: 67.5%
Below 19.6 pg/mL	44	90	NPV: 67.7%
	Sensitivity: 27.9%	Specificity: 91.8%
Peak sNfL % change
Above 68.8%	26	17	PPV: 59.9%
Below 68.8%	35	81	NPV: 70.4%
	Sensitivity: 42.6%	Specificity: 82.7%

Sensitivity: the proportion of people with Gd+ who were above the specified sNfL threshold compared with the total number of people who developed Gd+.

Specificity: the proportion of people with no Gd+ who were below the specified threshold of sNfL compared with the total number of people with no Gd+.

PPV: positive predictive value or probability that an elevation in sNfL above the identified threshold will have Gd+ lesions.

NPV: negative predictive value or the probability that the absence of an elevation in sNfL above the identified threshold will have Gd+ lesions.

Gd+ = gadolinium-enhancing; sNfL = serum neurofilament light.