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. 2024 Jan 22;78(6):1732–1744. doi: 10.1093/cid/ciae010

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© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Study design. Participants were randomized before RSV season 1 to receive 1 dose of RSV prefusion F protein–based vaccine (RSVPreF3 OA) or placebo. RSVPreF3 OA recipients were re-randomized before RSV season 2 to receive a second RSVPreF3 OA dose (RSV_revaccination group) or placebo (RSV_1dose group). Participants who received placebo pre–season 1 received a second placebo dose pre–season 2. Abbreviations: NH, Northern Hemisphere; RSV, respiratory syncytial virus; SH, Southern Hemisphere.