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. 2024 Mar 11;78(6):1680–1689. doi: 10.1093/cid/ciae119

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© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Comparable exposure from 600 mg rifampicin given as flat-dosing and weight-banded dosing. A total of 500 simulations were performed using a virtual population of persons with TB (N = 5687) consisting of demographic factors from 4 trials: S31/A5349 (NCT02410772), OFLOTUB (NCT00216385), REMoxTB (NCT00864383), and RIFAQUIN (ISRCTN44153044). In the standard 6-month control regimen, the flat-dosing strategy means administering rifampicin at 600 mg daily, while weight-banded dosing strategy means administering rifampicin daily based on weight bands (450 mg for patients weighing 40–50 kg and 600 mg for those weighing ≥55 kg). Abbreviations: AUC_ss area under the plasma concentration-time curve at steady state; TB, tuberculosis.