Table 3.
Hazard of Stable Culture Conversion and Tuberculosis-Related Unfavorable Outcome by Rifampicin Exposure
| Time Intervala | Rifampicin AUCss Below Median, Estimate (95% CI) | P b |
|---|---|---|
| Hazard ratio for time to stable culture conversion | ||
| 6-Month | 1.07 (.91–1.25) | .42 |
| Hazard ratio for time to TB-related unfavorable outcome | ||
| 9-Month | .40 (.08–2.11) | .28 |
| 12-Month | .44 (.15–1.26) | .13 |
| 18-Month | .73 (.29–1.82) | .50 |
The exposure of interest was rifampicin AUCss below the median of 41.8 mg·h/L in comparison to at or above the median of 41.8 mg·h/L (reference group).
Abbreviations: AUCss, area under the plasma concentration-time curve at steady state; CI, confidence interval; HIV, human immunodeficiency virus; TB, tuberculosis.
aTime interval was measured from the date of randomization.
bEach statistical test was adjusted for HIV status, Xpert MTB/RIF cycle threshold, extent of disease on chest radiograph, and site (African vs non-African site).