Figure 1.

SG generates weight loss and insulin resistance remission in DIO mice. (A) Flowchart about surgical interventions and postoperative assessments. (B) SG mice lose weight and maintain this weight loss relative to the Sham group. ITT test (C) and IPGTT test (E) were performed in the fourth and fifth week after surgery, respectively. (D, F) Corresponding area under the blood glucose curve was reduced in SG compared to sham-operated mice. Mice were sacrificed in a fasted state 6 weeks after surgery. Serum and liver samples were collected. (G) The HOMA-IR value was calculated by detecting the insulin and blood glucose values in the serum. (Data are shown as mean±SE. *=P<0.05, **=P<0.01, ***=P<0.001, and ****=P<0.0001. For panel B, n=12 Sham, 8 SG. For panel C, n=5 Sham and SG. For panels E and G, n=6 Sham and SG). DIO, diet-induced obese; IPGTT, intraperitoneal glucose tolerance testing; SG, Sleeve gastrectomy; ITT, insulin tolerance testing.