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. 2024 Apr 4;110(6):3307–3325. doi: 10.1097/JS9.0000000000001387

Figure 2.

Figure 2

SG significantly alleviates liver dysfunction in DIO mice. (A) Liver gross view of SG and Sham mice. (B) Liver-to-body ratio of SG and Sham mice. (C) Serum levels of major metabolic enzymes and apolipoproteins reflecting liver function changed after SG. (D) Histological examination using H&E staining revealed fat degeneration below 33%, no evidence of lobular inflammation, and NAS scores of 0–1. In the Sham group, mice displayed strong liver ultrasound signals and larger liver volume. H&E staining indicated fat degeneration exceeding 66%, with no Mallory bodies observed in either group. The Sham group received NAS scores of 4–5. (E) Liver section oil red O staining. (F) Liver section PAS staining. (G) The changes in the expression level of metabolism-related genes were shown by qRT-PCR results in the form of a heatmap. (Data are shown as mean±SE. ns=P>0.05, *=P<0.05, and **=P<0.01. For panels B and C, n=6 Sham and SG). DIO, diet-induced obese; SG, sleeve gastrectomy.