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. 2024 May 14;56(6):1147–1155. doi: 10.1038/s41588-024-01755-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a. Age distribution from UKBB. b. Pipeline for identifying exome wide selection on somatic mutations and new genes under positive selection in UKBB. c. Global dN/dS estimates per age group. Error bars represent the 95% CI of the dN/dS parameter for that mutation type and age group. N = 52,701 mutations. d. Percent of mutation type per age group. e. Number of mutations for each mutation type per age group.