Extended Data Fig. 2. Gene expression and poor health outcome associations of recurrently mutated clonal haematopoiesis genes.
Gene expression of new ‘fitness-inferred’ (FI)-driver genes in haematopoietic compartment. Expression data was taken from Corces et al.47. Common lymphoid progenitor, CLP; megakaryocyte-erythroid progenitor cell, MEP; common myeloid progenitor, CMP; granulocyte-macrophage progenitor cell, GMP; lymphoid-primed multipotent progenitor cell, LMPP; preleukemic HSC, pHSC; leukemia stem cells, LSC; erythroid cell, Ery; leukemic blast cell, blasts; multipotent progenitor cell, MPP; Mono, monocyte; NK cell, natural killer cell; HSC, haematopoietic stem cell. b, c. Logistic regression log odds ratios for a wide range of poor health outcomes for commonly mutated (genes with >35 mutations) driver genes of CH. Error bars represent the 95% CI. N = 200,618 individuals. Note the log odds ratio for JAK2 mutations and MPN is shown as ‘>’ as it is >5 (5.96, 95% CI 5.56–6.36). Acute lymphoblastic leukaemia, ALL; Common lymphoid malignancies, CLM; multiple myeloma and related, MM; chronic myeloid leukaemia, CML; acute myeloid leukaemia, AML; myelodysplastic diseases, MDS; myeloproliferative neoplasms, MPN; acute upper respiratory infection, AURI; acute lower respiratory infection, ALRI; intestinal infections, II. Orange shading refers to new FI genes of CH; classical FI genes of CH are shown in blue, and classical non FI CH genes are shown in green.