Extended Data Fig. 3. Clone size effect on poor health outcomes.
Clone size effect on poor-health outcomes (malignancy, stroke, death, different haematological neoplasms and infections) incidence by CH driver mutation category. Poor health outcomes incidence increases as clone variant allele frequency increases to 0.1 after which the relationship becomes unstable which has been noted previously for DNMT3A and TET2 mutant clones and cardiovascular risk. Error bars represent the 2*standard error of the mean incidence. The smoothed line represents a second degree polynomial fit of the actual data and the shading represents the 95% CI. N = 200,618 individuals. Orange shading refers to new FI genes of CH; classical FI genes of CH are shown in blue, and classical non FI CH genes are shown in green.