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. 2024 Jun 5;56(6):1090–1099. doi: 10.1038/s41588-024-01763-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a,b, Treemaps of significantly enriched (FDR < 0.05, one-sample one-sided Z-test (DEPICT) or one-sided t-test (MAGMA)) pathways. Respective GO terms were clustered based on their semantic similarity (method: Wang, GOSemSim as implemented in the rrvgo package version 1.2.0) using results from DEPICT (a) and results from MAGMA (b). Terms are presented in rectangles. Coloring indicates the membership of a term in a specific cluster. In addition, each cluster is visualized by thick border lines. The size of each rectangle corresponds to the significance of the enrichment. The most significantly enriched term in each cluster was selected as the representative term and is displayed in white font.