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. 2024 Jun 5;56(6):1090–1099. doi: 10.1038/s41588-024-01763-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Association results of replication stage. The effect size (beta) of the replication analysis is plotted against the effect size (beta) of the discovery stage for genome-wide significant lead SNPs. The color-coding and symbol shape indicate the strength of the association signal in the replication stage meta-analysis (nominal two-sided P value of random-effects meta-analysis). Blue square, Bonferroni-corrected significance; green circle, nominal significance; grey triangle, not significant. a, Pooled meta-analysis with Bonferroni threshold set at 0.000255, correcting for 196 lead SNPs. b, Male-specific meta-analysis with Bonferroni threshold set at 0.00082, correcting for 61 lead SNPs. c, Female-specific meta-analysis with Bonferroni threshold set at 0.000318, correcting for 157 lead SNPs.