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. 2024 Jun 13;10:45. doi: 10.1038/s41523-024-00646-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a MRI/CT scans of tumor metastases in brain and lung during one cycles of combination treatment in patient 1. b MRI/CT scans of tumor metastases in brain and lung during 12 cycles of combination treatment in patient 2. c, d The dynamic change of CEA, CA125, CA153, and CA199 during combination treatment in patients 1 and 2.