Table 4.
PIT TCRs sharing a single mismatched TRA chain with IAR T cells of known specificity. A
| TRA chain | TRB chain | |||||
|---|---|---|---|---|---|---|
| Specificity | V gene | Junction | J gene | V gene | Junction | J gene |
| GADp15 | TRAV41 | CAAA-GNQFYF | TRAJ49 | TRBV12-4 | CASSFT--YNEQFF | TRBJ2-1 |
| NDC | TRAV29/DV5B | CAAR-GNQFYF | TRAJ49 | TRBV6-2 | CASSLLNLDNEQFF | TRBJ2-1 |
| ND | TRAV21 | CAAI-GNQFYF | TRAJ49 | TRBV29-1 | CSVLRDRASYEQYF | TRBJ2-7 |
| ND | TRAV29/DV5 | CAASAGNQFYF | TRAJ49 | TRBV4-1 | CASSLAATRDDYGYTF | TRBJ1-2 |
| IGRP39 | TRAV25 | CAGQTGANNLFF | TRAJ36 | TRBV4-3 | CASSQEVGTVPNQPQHF- | TRBJ1-5 |
| ND | TRAV16 | CALQTGANNLFF | TRAJ36 | |||
| ND | TRAV13-1 | CATQTGANNLFF | TRAJ36 | TRBV9 | CASSVGR---SSYNEQFF | TRBJ2-1 |
| ND | TRAV24 | CASQTGANNLFF | TRAJ36 | TRBV4-1 | CASSQDPLTSGRGNEQFF | TRBJ2-1 |
| ZNP1 | TRAV13-1 | CAASGANSGYALNF | TRAJ41 | TRBV30 | CAWSAQGETQYF | TRBJ2-5 |
| ND | TRAV8-4 | CAVSGANSGYALNF | TRAJ41 | TRBV30 | CAWESGTRGNYGYTF | TRBJ1-2 |
| MultipleD | TRAV29DV5 | CAASRYSGGGADGLTF | TRAJ45 | TRBV12-4 | CASSPQGGNTEAFF | TRBJ1-1 |
| Multiple | TRAV29DV5 | CAASRYSGGGADGLTF | TRAJ45 | TRBV12-4 | CASSVQGGNTEAFF | TRBJ1-1 |
| ND | TRAV13-1 | CAASRSSGGGADGLTF | TRAJ45 | ND | ND | ND |
| Multiple | TRAV23DV6 | CAASNPDYKLSF | TRAJ20 | TRBV5-1 | CASSFTEGNTEAFF | TRBJ1-1 |
| ND | TRAV13-1 | CAASNNDYKLSF | TRAJ20 | TRBV28 | CASSGRAD--EQFF | TRBJ2-1 |
AShown are amino acid sequence comparisons of PIT TCRs having single mismatched TRA junctions with IAR TCRs of known specificity. The specificity of IAR TCRs is specified.
BBold font indicates a mismatch with the IAR reference sequence.
CND not determined.
DMultiple, IAR TCR with multiple specificities.