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. 2024 Jun 13;14:13630. doi: 10.1038/s41598-024-64561-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The enriched metabolic pathways for differentiating LIFE and CON groups using the Functional Analysis module in MetaboAnalyst. Top pathways significant (p < 0.05) in the analysis are annotated. A full list of enriched pathways is available in Supplementary Information Table S7. P1. Bile acid biosynthesis; P2. Histidine metabolism; P3. Lysine metabolism; P4. Heparan sulfate degradation; P5. Phytanic acid peroxisomal oxidation; P6. Glycosphingolipid metabolism; P7. Pyrimidine metabolism; P8. Chondroitin sulfate degradation; P9. N-Glycan degradation; P10. Aminosugars metabolism; P11. Beta-alanine metabolism; P12. Vitamin D3 (cholecalciferol) metabolism; P13. Glycosphingolipid biosynthesis—ganglioseries; P14. Glycosphingolipid biosynthesis—globoseries; P15. Butanoate metabolism; P16. Tyrosine metabolism. P4, P10, and P13 are not visible due to overlap.