Table 3.
The top 16 pathways (p ≤ 0.05) enriched and ranked in the Mummichog pathway analysis in MetaboAnalyst.
| Pathway name | Pathway totala | Hits.totalb | cHits.sigc | FETd |
|---|---|---|---|---|
| Bile acid biosynthesis | 82 | 50 | 42 | 0.000 |
| Histidine metabolism | 33 | 12 | 11 | 0.003 |
| Lysine metabolism | 52 | 15 | 15 | 0.005 |
| Heparan sulfate degradation | 34 | 3 | 3 | 0.006 |
| Phytanic acid peroxisomal oxidation | 34 | 5 | 5 | 0.006 |
| Glycosphingolipid metabolism | 67 | 15 | 13 | 0.009 |
| Pyrimidine metabolism | 70 | 19 | 16 | 0.011 |
| Chondroitin sulfate degradation | 37 | 3 | 3 | 0.015 |
| N-Glycan Degradation | 16 | 6 | 6 | 0.020 |
| Aminosugars metabolism | 69 | 8 | 8 | 0.025 |
| Beta-Alanine metabolism | 20 | 8 | 8 | 0.025 |
| Vitamin D3 (cholecalciferol) metabolism | 16 | 13 | 10 | 0.033 |
| Glycosphingolipid biosynthesis—ganglioseries | 62 | 4 | 4 | 0.034 |
| Glycosphingolipid biosynthesis—globoseries | 16 | 2 | 2 | 0.034 |
| Butanoate metabolism | 34 | 17 | 14 | 0.044 |
| Tyrosine metabolism | 160 | 63 | 48 | 0.047 |
aPathway total indicates the overall number of metabolites that are included in a specific pathway.
bHits.total indicates the number of measured signals that are matched (m/z error < 3 ppm) with the metabolites included in the pathway.
cHits.sig indicates the number of matched signals that were significantly changed between phenotypic groups.
dFET is the right-tail p-value determined by the Fisher Exact Test for pathway enrichment.