Table 1.
Information components (IC) calculated for CAR-T therapy (ND = 5,576) for the given adverse reactions
| Reaction Name | NA | NAD | IC | IC025 |
|---|---|---|---|---|
| Inflammatory/Effusive Events | ||||
| C-Reactive Protein Increased | 25,169 | 70 | 3.769 | 3.372 |
| Capillary Leak Syndrome | 1206 | 14 | 4.324 | 3.421 |
| Myocarditis | 28,484 | 2 | −1.211 | −3.804 |
| Pericarditis | 21,552 | 3 | −0.363 | −2.432 |
| Pericardial Effusion | 17,867 | 18 | 2.277 | 1.485 |
| Cardiac Tamponade | 2,897 | 0 | −1.053 | −11.377 |
| Arrhythmic Events | ||||
| Tachycardia | 202,122 | 174 | 2.198 | 1.948 |
| Atrial Fibrillation | 79,948 | 45 | 1.569 | 1.073 |
| Atrial Flutter | 6773 | 8 | 2.274 | 1.062 |
| Electrocardiogram QT Prolonged | 27,465 | 9 | 0.763 | −0.376 |
| Ventricular Tachycardia/Ventricular Fibrillation | 27,573 | 15 | 1.464 | 0.593 |
| Cardiac Arrest | 75,180 | 31 | 1.124 | 0.524 |
| Hemodynamic Events | ||||
| Hypotension | 268,722 | 469 | 3.220 | 3.068 |
| Sinus Tachycardia | 14,075 | 18 | 2.571 | 1.779 |
| Cardiomyopathy-Related Events | ||||
| Stress Cardiomyopathy | 2700 | 6 | 2.699 | 1.284 |
| Ejection Fraction Decreased | 10,708 | 11 | 2.209 | 1.184 |
| Cardiac Failure | 130,976 | 30 | 0.241 | −0.369 |
| Cardiogenic Shock | 7138 | 5 | 1.592 | 0.029 |
IC025 > 0 is an indicator for significant adverse reaction signals, which are highlighted in bold; ND number of reports containing a given medication in VigiBase, NA number of reports containing a given adverse reaction in VigiBase, NAD number of reports containing a given drug-adverse reaction pair in VigiBase.