Table 3.

Significant MR analysis results.

Cytokine taxa	MR method	No. SNP	OR	95%CI	p-value	p for MR-PRESSO global test
CCL19	IVW	13	0.70	0.52–0.94	0.02
	Weighted median		0.72	0.47–1.09	0.1236
	MR-Egger		0.68	0.39–1.17	0.19
	Simple mode		0.89	0.52–2.43	0.63
	MR-PRESSO					0.31
CXCL6	IVW	11	1.26	1.01	1.57
	Weighted median		1.20	1.02–1.42	0.03
	MR-Egger		1.06	0.78	1.42
	Simple mode		1.77	0.97–3.22	0.09
	MR-PRESSO					0.14
IL-6	IVW	8	0.66	0.44–0.98	0.04
	Weighted median		0.68	0.43–1.10	0.11
	MR-Egger		0.38	0.18–0.81	0.04
	Simple mode		0.71	0.36–1.41	0.36
	MR-PRESSO					0.08

OR, odds ratio; CI, confidence interval; SNP, single-nucleotide polymorphism; MR, Mendelian randomization; MR-PRESSO, MR pleiotropy residual sum and outlier.