Table 5.
Gene ontology (GO) enrichment analysis of the differentially expressed upregulated and downregulated genes in ΔccpC compared to the levels in the wildtype F2365 strain.
| Category | Description | p value | p-adj | Count |
|---|---|---|---|---|
| GO pathway enrichment analysis for upregulated genes in ΔccpC compared wildtype F2365 | ||||
| BP | Nucleic acid metabolic process | 5.5E-08 | 9.0E-06 | 66 |
| DNA repair | 9.3E-07 | 3.6E-05 | 38 | |
| Cellular response to stress | 9.3E-07 | 3.6E-05 | 15 | |
| Cellular response to stimulus | 3.0E-06 | 8.3E-05 | 23 | |
| Nucleobase-containing compound metabolic process | 1.1E-05 | 2.3E-04 | 72 | |
| Heterocycle metabolic process | 1.4E-05 | 2.7E-04 | 79 | |
| Cellular aromatic compound metabolic process | 1.7E-05 | 2.8E-04 | 78 | |
| Response to stimulus | 1.8E-05 | 2.8E-04 | 27 | |
| Organic cyclic compound metabolic process | 2.3E-05 | 3.3E-04 | 79 | |
| Cellular macromolecule metabolic process | 2.5E-05 | 3.5E-04 | 63 | |
| Regulation of cellular process | 2.0E-04 | 2.6E-03 | 43 | |
| Regulation of biological process | 2.3E-04 | 2.8E-03 | 43 | |
| Cellular nitrogen compound metabolic process | 3.4E-04 | 3.9E-03 | 81 | |
| Regulation of nucleobase-containing compound metabolic process | 4.7E-04 | 4.4E-03 | 36 | |
| Regulation of cellular metabolic process | 4.7E-04 | 4.4E-03 | 36 | |
| Regulation of nitrogen compound metabolic process | 4.7E-04 | 4.4E-03 | 36 | |
| Regulation of macromolecule metabolic process | 4.7E-04 | 4.4E-03 | 36 | |
| Regulation of primary metabolic process | 5.5E-04 | 4.4E-03 | 36 | |
| Biological regulation | 5.7E-04 | 4.4E-03 | 43 | |
| Regulation of macromolecule biosynthetic process | 9.0E-04 | 6.0E-03 | 35 | |
| GO pathway enrichment analysis for downregulated genes in ΔccpC compared wildtype F2365 | ||||
| BP | Phosphoenolpyruvate-dependent sugar phosphotransferase system | 1.0E-06 | 8.2E-05 | 66 |
| Establishment of localization | 2.3E-06 | 8.2E-05 | 66 | |
| Localization | 2.1E-06 | 8.2E-05 | 67 | |
| Cobalamin biosynthetic process | 1.0E-04 | 2.5E-03 | 7 | |
| Vitamin metabolic process | 9.7E-04 | 1.5E-02 | 9 | |
| Water-soluble vitamin biosynthetic process | 9.7E-04 | 1.5E-02 | 9 | |
| Tetrapyrrole metabolic process | 3.1E-03 | 4.3E-02 | 8 | |
| MF | Protein-N(PI)-phosphohistidine-sugar phosphotransferase activity | 1.7E-05 | 1.9E-03 | 16 |
| Carbohydrate transmembrane transporter activity | 4.4E-05 | 2.5E-03 | 16 | |
| Phosphotransferase activity, alcohol group as acceptor | 9.1E-05 | 3.4E-03 | 23 | |
| Active transmembrane transporter activity | 2.2E-04 | 6.3E-03 | 22 | |
| Transporter activity | 6.6E-04 | 1.5E-02 | 33 | |
| Carbon–carbon lyase activity | 1.3E-03 | 2.5E-02 | 7 | |
| Transferase activity, transferring phosphorus-containing groups | 4.6E-03 | 7.4E-02 | 27 | |
| Lyase activity | 6.2E-03 | 8.8E-02 | 11 | |
| Transmembrane transporter activity | 7.1E-03 | 8.9E-02 | 24 | |