Figure 4.

Manhattan plots of subtype-specific IBS ΩGWAS meta-analyses. Each circle denotes a marker with regard to its physical location (based on the Genome Reference Consortium Human Build 37) and associated -log₁₀P value. SNPs reaching the genome-wide significance threshold (P = 5×10^-8, indicated with a horizontal red line) are colored in green. Suggestive significance threshold (P = 5×10^-6) is indicated with a horizontal blue line. The lead SNP rs ID and its respective best candidate protein-coding gene symbol are annotated in green.