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Rome III IBS PRS testing analysis. Prevalence of IBS across PRS percentiles (polynomial regression fitting line in black), and OR relative to various upper percentiles compared with the rest of the population (estimated from logistic regression adjusted for sex, 10 top principal components, and genotyping array). The testing cohort consisted of IBS cases (n = 5336) and control subjects (n = 141,436) identified based on ICD10 K58 (for IBS) and self-reported IBS diagnosis.
