Table 1.
Demographics of Study Cohorts Included in Rome III IBS GWAS Meta-analyses
| Cohort | N | Age, mean (SD) | Sex, female (%) | |
|---|---|---|---|---|
| UKBB | IBS | 22,745 | 54.4 (7.7) | 73.0 |
| IBS-M | 12,335 | 56.6 (7.6) | 72.4 | |
| IBS-D | 5,920 | 54.2 (7.7) | 67.4 | |
| IBS-C | 3,855 | 55.0 (7.8) | 83.9 | |
| Control subjects | 66,631 | 56.6 (7.6) | 46.9 | |
| LL | IBS | 1,990 | 42.5 (14.0) | 76.2 |
| IBS-M | 797 | 40.4 (14.2) | 78.9 | |
| IBS-D | 561 | 43.1 (13.4) | 67.9 | |
| IBS-C | 475 | 44.0 (14.1) | 84.0 | |
| Control subjects | 10,518 | 47.2 (13.8) | 48.0 | |
GWAS, genome-wide association study; IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome constipation-predominant subtype; IBS-D, irritable bowel syndrome diarrhea-predominant subtype; IBS-M, irritable bowel syndrome mixed subtype; LL, Lifelines; SD, standard deviation; UKBB, UK Biobank.