Table 2.
Number of ICD10 Comorbidities in UKBB Subjects
| Cohort | Number of ICD10 comorbidities |
||
|---|---|---|---|
| Mean (SD) | Beta (SE) | P (Beta)a | |
| IBS | 4.5 (5.1) | 1.81 (0.03) | <1.0E-300 |
| IBS-M | 4.7 (5.3) | 2.02 (0.04) | <1.0E-300 |
| IBS-D | 4.1 (4.6) | 1.42 (0.05) | 5.1E-161 |
| IBS-C | 4.6 (5.3) | 1.93 (0.06) | 1.9E-194 |
| Control subjects | 3.0 (3.9) | — | — |
IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome constipation-predominant subtype; IBS-D, irritable bowel syndrome diarrhea-predominant subtype; IBS-M, irritable bowel syndrome mixed subtype; ICD10, International Classification of Diseases, 10th revision; SD, standard deviation; SE, standard error; UKBB, UK Biobank.
a
From sex- and age-adjusted linear regression, testing the effect of IBS on the number of ICD10 comorbidities. Comorbidities included ICD10 codes for diseases (Chapters I-XIV) and laboratory findings (Chapter XVIII), excluding K58 for IBS and confounding gastrointestinal diagnoses (see Methods).