Table 3.
Chapter-Level ICD10 Comorbidities in UKBB Subjects
| ICD10 Chapter | OR (95% CI) |
P value (FDR)a |
||||||
|---|---|---|---|---|---|---|---|---|
| IBS | IBS-M | IBS-D | IBS-C | IBS | IBS-M | IBS-D | IBS-C | |
| I Certain infectious and parasitic diseases | 2.1 (1.9–2.2) | 2.2 (2.1–2.4) | 2.0 (1.8–2.2) | 1.9 (1.6–2.1) | 5.0E-104 | 1.4E-87 | 6.5E-35 | 4.2E-19 |
| II Neoplasms | 1.2 (1.2–1.3) | 1.2 (1.2–1.3) | 1.3 (1.2–1.3) | 1.3 (1.2–1.4) | 3.5E-28 | 3.2E-17 | 3.0E-10 | 4.4E-10 |
| III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | 1.5 (1.4–1.7) | 1.6 (1.5–1.8) | 1.4 (1.2–1.6) | 1.6 (1.4–1.9) | 3.1E-30 | 3.8E-27 | 9.5E-06 | 6.0E-10 |
| IV Endocrine, nutritional and metabolic diseases | 1.6 (1.5–1.7) | 1.8 (1.7–1.9) | 1.5 (1.4–1.6) | 1.5 (1.4–1.7) | 2.0E-100 | 3.2E-98 | 3.3E-22 | 9.6E-18 |
| V Mental and behavioral disorders | 2.2 (2.1–2.4) | 2.4 (2.3–2.6) | 2.0 (1.8–2.2) | 2.3 (2.0–2.6) | 4.1E-140 | 2.3E-120 | 7.7E-39 | 3.3E-39 |
| VI Diseases of the nervous system | 1.7 (1.6–1.8) | 1.8 (1.7–1.9) | 1.5 (1.4–1.7) | 1.8 (1.6–2.0) | 4.4E-80 | 1.2E-63 | 3.3E-18 | 2.3E-27 |
| VII Diseases of the eye and adnexa | 1.2 (1.1–1.3) | 1.2 (1.1–1.3) | 1.2 (1.0–1.3) | 1.2 (1.0–1.3) | 8.3E-10 | 4.7E-08 | 1.4E-02 | 3.8E-02 |
| VIII Diseases of the ear and mastoid process | 1.5 (1.4–1.7) | 1.6 (1.4–1.8) | 1.5 (1.3–1.8) | 1.6 (1.3–2.0) | 8.2E-15 | 2.8E-11 | 1.8E-05 | 3.0E-05 |
| IX Diseases of the circulatory system | 1.6 (1.6–1.7) | 1.7 (1.7–1.8) | 1.5 (1.4–1.6) | 1.6 (1.5–1.7) | 1.3E-146 | 7.5E-125 | 1.3E-33 | 7.5E-33 |
| X Diseases of the respiratory system | 1.7 (1.6–1.8) | 1.8 (1.7–1.9) | 1.5 (1.4–1.6) | 1.7 (1.6–1.9) | 5.2E-106 | 2.8E-90 | 2.4E-23 | 1.9E-28 |
| XI Diseases of the digestive system | 2.5 (2.4–2.6) | 2.7 (2.5–2.8) | 2.3 (2.2–2.4) | 2.6 (2.4–2.8) | <1.0E-300 | <1.0E-300 | 1.5E-178 | 1.8E-157 |
| XII Diseases of the skin and subcutaneous tissue | 1.3 (1.2–1.4) | 1.3 (1.2–1.4) | 1.3 (1.2–1.4) | 1.3 (1.1–1.4) | 1.3E-19 | 1.8E-16 | 3.0E-06 | 1.2E-04 |
| XIII Diseases of the musculoskeletal system and connective tissue | 1.5 (1.4–1.5) | 1.6 (1.5–1.6) | 1.3 (1.3–1.4) | 1.5 (1.4–1.7) | 1.2E-102 | 1.0E-85 | 2.0E-20 | 3.4E-30 |
| XIV Diseases of the genitourinary system | 1.5 (1.5–1.6) | 1.6 (1.6–1.7) | 1.4 (1.3–1.5) | 1.7 (1.5–1.8) | 1.0E-123 | 3.3E-101 | 3.6E-28 | 6.4E-41 |
| XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | 2.1 (2.1–2.2) | 2.3 (2.2–2.4) | 2.0 (1.9–2.1) | 2.2 (2.0–2.4) | <1.0E-300 | <1.0E-300 | 1.4E-119 | 1.8E-108 |
CI, confidence interval; FDR, false discovery rate; IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome constipation-predominant subtype; IBS-D, irritable bowel syndrome diarrhea-predominant subtype; IBS-M, irritable bowel syndrome mixed subtype; ICD10, International Classification of Diseases, 10th revision; OR, odds ratio; SD, standard deviation; SE, standard error; UKBB, UK Biobank.
From sex- and age-adjusted logistic regressions, comparing the risk of ICD10 diagnoses (at the chapter level) in IBS cases versus control subjects. Nonsignificant results (FDR >0.05) are omitted (indicated by a dash). Only ICD10 chapters for diseases (Chapters I-XIV) and laboratory findings (Chapter XVIII) are included, excluding K58 for IBS and confounding gastrointestinal diagnoses (see Methods).