Table 9.

Demographics of UKBB Study Cohorts Included in PRS Analyses

Cohort		N	Age, mean (SD)	Sex, female (%)
Subset 1 (PRS computation)	IBS	5,335	57.0 (8.1)	73.9
	Control subjects	141,436	57.2 (8.2)	52.2
Subset 2 (PRS testing)	IBS	5,336	56.9 (8.1)	74.8
	Control subjects	141,436	57.2 (8.2)	52.1

NOTE. IBS cases and control subjects for PRS analyses were identified based on ICD10 K58 (code for IBS) and self-reported IBS diagnosis from touchscreen questionnaire (see Methods).

IBS, irritable bowel syndrome; ICD10, International Classification of Diseases, 10th revision; PRS, polygenic risk score; SD, standard deviation; UKBB, UK Biobank.