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. 2024 Jun 14;22:333. doi: 10.1186/s12951-024-02533-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Differential miRNA profiles of ABs were produced by 3D cultivation of mADSCs. (A) Principal component analysis (PCA) of the miRNAs in 2D- and 3D-ABs was carried out. (B) To show which miRNAs were differently expressed, a volcano plot was created. (C) Target genes linked to biological processes that were inferred from differentially expressed miRNAs in 3D-ABs underwent GO analysis. (D) Target genes identified from differentially expressed miRNAs in 3D-ABs were analyzed using the KEGG. (E) In comparison to 2D-ABs, the top 10 miRNAs that were up- and down-regulated in 3D-ABs were plotted on a heatmap. (n = 4) (F) Compared to 2D-ABs, the biological roles of the top 10 up- and down-regulated miRNAs in 3D-ABs were investigated