. Author manuscript; available in PMC: 2024 Jun 14.

Published in final edited form as: Pediatr Res. 2019 Oct 24;87(2):309–318. doi: 10.1038/s41390-019-0581-7

Table 1.

Differential exercise regulation of monocyte genes previously associated with inflammation and/or CAD

Gene	CAD	Exercise	Possible mechanisms
CD36	↑	↓	Facilitates scavenging of modified LDL and activates inflammatory pathways¹³¹
TLR4	↑	↓	Pathogenesis and destabilization of atherosclerotic plaques¹³²
VCAN	↑	↓	Versican is involved in advanced lesions of atherosclerosis at the borders of lipid-filled necrotic cores as well as at the plaque–thrombus interface¹³³
DNAJB6	↑	↓	Controls HSP function, known to be a key immune modulator in atherosclerotic plaques¹³⁴
FAM198B	↑	↓	As yet unknown
HIST1H2BG	↑	↓	Histone modification is a critical component of a transcriptional cascade regulating SMC proliferation and might play a role in the development of proliferative vascular diseases¹³⁵

All data from human subjects. Data from coronary artery disease (CAD) patients is derived from previous studies. The exercise data is from our recent study in healthy people