Table 2.
microRNAs in monocytes significantly (FDR ≤0.05) affected (FC) by exercise and their possible connection to atherosclerosis [exercise data from our publication13]
| microRNA | FC | Possible link to atherosclerosis |
|---|---|---|
| miR-130a | ↓1.5 | Involved in angiogenesis in endothelial progenitor cells;136 serum biomarker for atherosclerosis137 |
| miR-221 | ↓1.3 | Involved in vascular remodeling; regulation of monocytes into dendritic cells138 |
| miR-23b | ↓1.3 | Controls immune tolerance in dendritic cells; plays an atheroprotective role in shear stress vascular remodeling139 |
| miR-29b | ↑1.9 | Plays a key role in the mechanisms through which LDLs alter vascular smooth muscle function; significantly upregulated in atherosclerotic aortic aneurysm tissue;140 inhibits migration and proliferation of vascular smooth muscle cells in neointimal formation141 |
| miR-362-3p | ↑1.4 | Downregulated more than twofold in both brain and blood following experimental injury to the cerebral vasculature142 |
| miR-660 | ↑1.4 | Increases the efficiency of ex vivo platelet generation;143 predicts future fatal myocardial infarction in healthy individuals144 |
| miR-140-5p | ↑1.3 | Circulating levels are elevated in severely obese individuals145 |
| miR-532-5p | ↑1.3 | Circulating levels are elevated in severely obese individuals145 |
| miR-30e | ↑1.3 | Substantially downregulated in animal model of atherosclerotic lesions;146 inhibits neointimal hyperplasia by targeting calmodulin-dependent protein kinase147 |
| miR-15a | ↑1.3 | Involved in blood–brain barrier disruption in animal models of vascular injury;148 associated with abdominal aortic aneurysms and peripheral arterial disease149 |
FC fold change