Table 10.

Role of miRNA in the pathogenesis of Huntington’s disease.

miRNA	Role in HD	References
miR-9	It is downregulated in HD and is associated with transcriptional dysregulation. It targets genes that play essential roles in HD pathophysiology.	Packer et al. (2008)
miR-10b-5p	Upregulated in HD, potentially promoting striatal involvement in the disease. In normal circumstances, it controls the level of BDNF.	Hoss et al. (2015a)
miR-146a	Exerts a negative regulatory effect on the NF-κB pathway, and its expression is diminished in HD. It specifically targets genes that regulate the cell cycle and apoptosis, perhaps aiding in correcting anomalies in these processes.	Sinha et al. (2010)
miR-196a	It is upregulated in HD and is associated with reduced cytotoxicity and apoptosis. It improves mitochondrial function and morphology by upregulating essential genes like CBP and PGC-1α.	Cheng et al. (2013) and Fu et al. (2015)
miR-214	Upregulated and targets the HTT gene. It may influence the aggregation of mHTT and impact mitochondrial morphology and cell cycle regulation.	Bucha et al. (2015) and Dong and Cong (2021)