Table 3.
List of reported microRNAs in amyotrophic lateral sclerosis.
| Source | miRNA | Expression | Methods | References |
|---|---|---|---|---|
| Serum | miR-338-3p | Upregulated | RT-qPCR | De Felice et al. (2014) |
| miR-106b, miR-206 | Upregulated | Microarray, qPCR | Toivonen et al. (2014) | |
| miR-192-3p, miR-133b, miR-19a-3p, miR-144-5p, miR-195-5p, miR-133a-3p | Upregulated | RT-qPCR | Raheja et al. (2018) | |
| miR-206, miR-133b, miR-133a | Upregulated | RT-qPCR | Tasca et al. (2016) | |
| miR-143-3p, iR-206, | Upregulated | RT-qPCR | Waller et al. (2017) | |
| miR-142-3p | Upregulated | Microarray, RT-qPCR | Matamala et al. (2018) | |
| miR-1249-3p | Downregulated | Microarray, RT-qPCR | Matamala et al. (2018) | |
| miR-320b, miR-320c, let-7d-3p, miR-320a, miR-425-5p, miR-139-5p | Downregulated | RT-qPCR | Raheja et al. (2018) | |
| miR-146a, miR-27a, miR-149, | Downregulated | RT-qPCR | Tasca et al. (2016) | |
| let-7b, miR-143-3p, miR-143-5p, miR-132-5p, miR-132-3p, | Downregulated | RT-qPCR | Freischmidt et al. (2013) | |
| miR-374b-5p | Downregulated | RT-qPCR | Waller et al. (2017) | |
| miR-3665, miR-4745-5p, miR-4530, miR-1915-3p | Downregulated | Microarray, RT-qPCR | Freischmidt et al. (2014) | |
| miR-1234-3p, miR-1825 | Downregulated | Microarray, RT-qPCR | Freischmidt et al. (2015) | |
| Serum exomes | miR-27a-3p | Downregulated | RT-qPCR | Xu et al. (2018) |
| Plasma | miR-206, miR-424 | Upregulated | Microarray, RT-qPCR | de Andrade et al. (2016) |
| miR-4258, miR-663b, miR-4649-5p | Upregulated | Microarray, RT-qPCR | Takahashi et al. (2015) | |
| miR-26b-5p, miR-4299, let-7f-5p, | Downregulated | Microarray, RT-qPCR | Takahashi et al. (2015) | |
| miR-9, miR-335-5p, miR-129-3p | Downregulated | RT-qPCR | Sheinerman et al. (2017) | |
| Whole blood | let-7b, miR-9, miR-338, miR-206, miR-132, miR-451a, miR-638, miR-663a, miR-124a | Upregulated | RT-qPCR | Vrabec et al. (2018) |
| miR-338-3p | Upregulated | Microarray, RT-qPCR | De Felice et al. (2012) | |
| miR-193b, miR-3935, miR-451, miR-183 | Downregulated | Microarray, RT-qPCR | Chen Y. et al. (2016) | |
| miR-451, miR-1275, miR-665, miR-638, miR-149, miR-328 | Downregulated | Microarray, RT-qPCR | De Felice et al. (2012) | |
| Peripheral blood | miR-584-5p, miR-93-5p, miR-550a-3p, miR-532-5p, miR-451a, miR-425-5p, miR-3p, miR-30c-5p, miR-30b-5p, miR-28-3p, miR-27b-3p, miR-26b-5p, miR-26a-5p, miR-23a-3p, miR-223-3p, miR-221-3p, miR-22-3p, miR-186-5p, miR-183-5p, miR-182-5p, miR-16-5p, miR-151b, miR-151a-5p, miR-15b-5p, miR-15a-5p, miR-148b-3p, miR-148a-3p, miR-144-5p, miR-130b-3p, miR-130a-3p, miR-128-3p, miR-106b-3p, miR-103a-3p, let-7i-5p, let-7 g-5p, let-7f-5p, let-7d-5p, let-7a-5p. | Downregulated | NGS, RT-qPCR | Liguori et al. (2018) |
| CSF | miR-338-3p | Upregulated | RT-qPCR | De Felice et al. (2014) |
| miR-9-5p, miR-127-3p, miR-143-3p, miR-27b-3p, miR-124-3p, miR-125b-3p | Upregulated | Illumina Small RNA Sequencing, RT-qPCR | Waller et al. (2018) | |
| miR-181a-5p | Upregulated | RT-qPCR | Benigni et al. (2016) | |
| miR-574-5p, miR-143-5p, | Upregulated | RT-qPCR | Freischmidt et al. (2013) | |
| miR-124 | Downregulated | RT-qPCR | Yelick et al. (2020) | |
| miR-143-3p, miR-132-5p, miR-132-3p, | Downregulated | RT-qPCR | Freischmidt et al. (2013) | |
| let7f-5p, let7a-5p, let7b-5p, miR-21-5p, miR-148-3p, miR-195a-5p, miR-15b-5p | Downregulated | RT-qPCR | Benigni et al. (2016) | |
| let7f-5p, miR-142-5p, miR-28-3p, miR-150-5p, miR-16-5p, miR-92a-5p, miR-146a-3p, miR-378a-3p | Downregulated | NGS | Waller et al. (2018) |