Table II.
Estimates and Their Percent Relative Standard Errors (%RSE) of the Population Parameters for the Base and Final Models
| Parameter | Estimate of typical value (%RSE) Base | Estimate of IIV (%RSE, %CV) Base | Estimate of typical value (%RSE) Final | Estimate of IIV (%RSE, %CV) Final |
|---|---|---|---|---|
| PNA50(day) | 2.31 (3.8) | 0.413 (9.2, 71.5) | NA | 0.220 (10.7, 49.6) |
| PNA50AKI=0(day) | NA | NA | 1.94 (3.5) | NA |
| PNA50AKI=1(day) | NA | NA | 6.21 (10.8) | NA |
| GFRSS/GFR0 | 1.78 (2.3) | 0.107 (8.7, 33.6) | 1.74 (2.0) | 0.0955 (7.9, 31.7) |
| ksyn/GFR0(mg/dL) | 0.654 (1.4) | 0.0233 (15.2, 15.4) | NA | 0.0180 (16.6, 13.5) |
| ksyn/GFR0AKI=0DEATH=0, (mg/dL | NA | NA | 0.631 (1.4) | NA |
| ksyn/GFR0AKI=1DEATH=0(mg/dL) | NA | NA | 0.785 (2.9) | NA |
| ksyn/GFR0AKI=0DEATH=1(mg/dL) | NA | NA | 0.750 (2.9) | NA |
| ksyn/GFR0AKI=1DEATH=1(mg/dL) | NA | NA | 0.834 (4.4) | NA |
| γ | 5.26 (9.2) | 0.435 (18.8, 73.9) | NA | 0.168 (28.4, 42.8) |
| γ AKI=0 | NA | N A | 4.46 (7.7) | NA |
| γ AKI=1 | NA | NA | 22.8 (28.2) | NA |
| K(1/day) | 0.709** (3.3) | 0.207** (13.9, 48.0) | 0.709** (3.3) | 0.207** (13.9, 48.0) |
| PNAp(day) | 2.42** (1.5) | 0.11** (7.0, 34.1) | 2.42** (1.5) | 0.11** (7.0, 34.1) |
| Qmax/UF | 0.575** (3.2) | 0.153** (9.4, 40.7) | 0.575** (3.2) | 0.153** (9.4, 40.7) |
| GA_PNAp(day/week) | −0.0747** (4.8) | NA | −0.0747** (4.8) | NA |
| GA_Qmax/UF(1/week) | 0.0178** (27.9) | NA | 0.0178** (27.9) | NA |
| σ2 | 0.0218 (3.3) | NA | 0.0227 (3.2) | NA |
Estimates of IIV parameters are presented as variance and coefficient of variation for lognormal distribution (%CV*)
NA not applicable,
glomerular filtration rate (GFR) value at steady state, GFR GFR value at birth, postnatal age (PNA) at which GFR is equal to 50% of sCr synthesis rate constant, Hill factor, time scale factor that controls the width of the back-flow curve PNA at the back-flow peak, back-flow peak value, urinary flow, slope in the covariate relationship between PNAp and GA, slope in the covariate relationship between Qmax/UF and variance of residual error for sCr observations
Parameter was fixed at value obtained from (12)