Table 3.
Differences in whole-brain, voxel-wise functional connectivity between clusters of JFM patients with lower and higher resilience compared to pain-free adolescents
| Contrast | Brain Region | Cluster Size | MNI coord. (x, y, z) | T | pFDR | Cohen's d |
|---|---|---|---|---|---|---|
| Pain-free > JFM higher resilience | Paracentral Lobule | 143 | −8, −26, 76 | 4.18 | .013 | 1.12 |
| Pain-free > JFM lower resilience | Sup Frontal Gyrus R | 176 | 14, 38, 38 | 5.73 | .001 | 1.47 |
| Mid Temporal Gyrus R | 272 | 72, −34, −14 | 5.39 | <.001 | 1.38 | |
| Paracentral Lobule | 1006 | −4, −26, 60 | 5.33 | <.001 | 1.36 | |
| Calcarine/ Lingual Gyri | 834 | 24, −66, 10 | 5.25 | <.001 | 1.34 | |
| Mid/Inf Frontal Gyrus L | 318 | −40, 58, 2 | 5.07 | <.001 | 1.30 | |
| Mid Frontal Gyrus R | 150 | 40, 52, 0 | 4.98 | .003 | 1.27 | |
| Inf Temporal Gyrus L | 227 | −50, −16, −32 | 4.97 | <.001 | 1.27 | |
| Sup Frontal Gyrus R | 115 | 16, 8, 56 | 4.90 | .009 | 1.25 | |
| Mid/Sup Frontal Gyrus L | 134 | −26, 6, 46 | 4.86 | .005 | 1.24 | |
| Inf Temporal Gyrus R | 310 | 38, −14, −38 | 4.79 | <.001 | 1.23 | |
| Lingual Gyrus R | 98 | 10, −44, −6 | 4.73 | .017 | 1.21 | |
| Sup Parietal Gyrus L | 209 | −18, −74, 52 | 4.73 | <.001 | 1.21 | |
| Angular Gyrus R | 125 | 50, −52, 28 | 4.72 | .007 | 1.21 | |
| Precentral Gyrus L | 121 | −48, 0, 28 | 4.71 | .008 | 1.21 | |
| Postcentral Gyrus R | 183 | 42, −40, 58 | 4.69 | .001 | 1.20 | |
| Sup Frontal Gyrus R | 91 | 18, 60, 4 | 4.59 | .022 | 1.17 | |
| Angular Gyrus L | 350 | −58, −60, 34 | 4.43 | <.001 | 1.13 | |
| Inf Parietal Lobule L | 105 | −54, −26, 50 | 4.43 | .014 | 1.13 | |
| MCC | 80 | 2, −24, 34 | 4.37 | .033 | 1.12 | |
| Lingual Gyrus L | 136 | −14, −42, −8 | 4.34 | .005 | 1.11 | |
| MCC L | 75 | −12, −24, 34 | 4.33 | .039 | 1.11 | |
| Mid/Sup Temporal Gyrus L | 84 | −62, −14, 0 | 4.32 | .029 | 1.11 | |
| Med/Sup Frontal Gyrus R | 74 | 10, 26, 60 | 4.29 | .040 | 1.10 | |
| Inf/Sup Parietal Lobule L | 75 | −28, −56, 48 | 4.21 | .039 | 1.08 | |
| Precuneus R | 302 | 28, −78, 34 | 4.18 | <.001 | 1.07 | |
| Rolandic Operculum L | 88 | −42, −18, 16 | 4.03 | .025 | 1.03 | |
| Lingual Gyrus L | 99 | −16, −70, −10 | 4.01 | .017 | 1.03 |
Note: If R/L (right/left) is not specified, the cluster was bilateral. Cluster size is presented in number of voxels. Inf: Inferior; JFM: Juvenile fibromyalgia; L: Left; MCC: Midcingulate Cortex; Med: Medial; Mid: Middle; MNI coord: Montreal Neurological Institute coordinates; PCC: Posterior Cingulate Cortex; PCL: Paracentral Lobule; pFDR: False Discovery Rate cluster-level corrected p-value; R: Right. Sup: Superior.