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CD4- and CD8-dependent lymphocytes in tumor eradication by rAAV E7CTL-hsp vaccination. KOI (CD8-deficient) (A) and KOII (CD4-deficient) (B) mice were subcutaneously injected with 5 × 104 TC-1 tumor cells. One week later, they were divided into two groups for treatments with 5 × 1010 viral particles of rAAV lacZ or rAAV E7CTL-hsp. Each group consists of six mice. Tumor volume was checked once a week.
