Table 4. irAEs per organ system in EC patients after treatment with ICI stratified by BMI.
Absolute number and percentage of irAEs per organ system across BMI categories Normal - BMI: 18.5 – 24.9 kg/m2; Overweight – BMI 25 – 29.9 kg/m2; Obese – BMI > 30 kg/m2. P-values were calculated with chi-squared or Fisher’s exact test. BMI, body mass index; EC, endometrial cancer; ICI, immune checkpoint inhibitor; irAEs, immune related adverse events.
| BMI (Kg/m2) | Hypo thyroidism | Hyper thyroidism | Skin | Colitis | Hepatitis/pancreatitis | Rheumatoid | Other endocrine | Nephritis |
|---|---|---|---|---|---|---|---|---|
| Normal (18.5 – 24.9) - No (%) | 35 (27) | 13 (10) | 7 (5) | 9 (7) | 5 (4) | 1 (0.8) | 1 (0.8) | 1 (0.8) |
| Overweight (25 – 29.9) – No (%) | 53 (33) | 20 (12) | 9 (6) | 13 (8) | 6 (4) | 4 (2) | 5 (3) | 3 (2) |
| Obese (≥ 30) – No (%) | 90 (39) | 41 (18) | 17 (7) | 16 (7) | 10 (4) | 8 (3) | 6 (3) | 4 (2) |
| Total - No (%) | 179 (34) | 74 (14) | 33 (6) | 38 (7) | 21 (4) | 13 (2) | 12 (2) | 8 (2) |
| p value | 0.1 | 0.1 | 0.7 | 0.9 | 1 | 0.3 | 0.5 | 0.8 |