Figure 1.
Mechanism of action of vPDT at the site of the blood vessel wall.7 Verteporfin PDT induces endothelial damage, including rounding of endothelial cells, which allows for clotting factors to be released at the site of damage and subsequent recruitment of platelets that form an occlusion. Adapted from Debefve E, Pegaz B, van den Bergh H, Wagnieres G, Lange N, Ballini JP. Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne), in the CAM model. Angiogenesis. 2008;11(3):235–243. Creative Commons.7
Abbreviations: von-WF, von Willebrand; vPDT, verteporfin photodynamic therapy.