Fig. 5.

Schematic representation of the effects of C. maritimum on HCC cell lines with different degrees of tumorigenicity and Warburg phenotype. As described in the text, C. maritimum prevents lipid accumulation, reduces the expression of key genes that control lipogenesis, and selectively promotes the normalisation of metabolic markers of cellular health. Specifically, insulin signalling was inhibited in the highly tumorigenic/Warburg-dependent cell lines Huh7 and HLE, whereas it was promoted in the low tumorigenic/OXPHOS-dependent cell lines HepaRG and HepG2