Table 4.

Key amino acid residues between Tiliroside and the active sites of targets

Bonding type / Targets	6F9U	6F9V	1DIC	2WWP	2XYF	3FMZ	1BIK	3QKG
Hydrophilic	Tyr523, Phe391, Val518, Tyr360, Trp357, Ala356, Phe512, Val351, Ala63, and Tyr62	Tyr501, tyr369, Val36, Tyr338, Trp335, Ala334, Ala332, Val329, Phe490	Val213, Ile227, Cys191, Leu41, Cys42, Cys58, Pro96, and Ile99	Tyr105, Phe34, Leu102, Ala99, Pro98, Pro71, and Ala72	Trp95, Val93, Ile92, Pro90, Leu40, Tyr78, Ala79	Met73, Phe135, Tyr133, Leu37, Tyr90, Met88, Phe96, Val61, and Leu63	Pro90, Val87, Tyr112, Cys115, Cys51, Ala50, and Trr42	Tyr79, Ala78, Tyr90, Met99, Met62, Met44, Leu37, and Ile30
Polar	Arg522, Glu411, His378, Asp358, Glu384, Lys368, Ser355, His353, Asn70, Asn66, and Glu143	Arg500, Arg381, Thr496, Glu389, His388, Asn494, Ser39, His365, Asp336, Glu362, His361, Ser333, His331, Lys346, and Asp43	Ser195, Ser190, Thr214, Ser215, Ser217, Arg218, Asp194, Glu60, Asp97, Hid57, Thr98, and Lys192	Gln36, Ser104, Ser101, Thr73, and Asp74	Lys94, Kys91, Gln89, Asn42, Lys41, and Glu44	Gln98, Lys99, Arg121, Asn101, and Asp102	Asn118, Gln116, Thr53, Ser48, Asn45, Glu52, and Glu69	Thr63, Ser64, Arg66, Thr75, Ser76, Lys118, Thr116, Thr128, and Lys130
Hydrogenous	Arg522, Glu411, Glu143, Asn70, Ala356, and Asn66	Asn494, Glu362, Asp336, Tyr338, Arg381, and Glu389	Ile227, Thr214, Gly216, Leu41, Cys42, Arg218, and Lys192	Ala72, Asp74, Tyr105, Gln36, Gly100, Gly103, Ser10, Gly100, and Ala99	Pro90, Lys91, Lys94, Glu77	Arg121, Glu33, Tyr133,Asp102, Gln98, and Asn101	Gly117, Thr53, and Thr42	Ala78, Tyr79, Thr128, Lys130, Arg66, Ser64, and Thr75