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. 2024 Jun 14;16:128. doi: 10.1186/s13195-024-01491-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlation matrix. Correlogram of the following selected variables: Brain-predicted age difference (BPAD), brain age, Mini-Mental State Examination (MMSE) score and chronological age (Age). Figures are color-coded based on diagnostic index; healthy controls, HC (red), subjective cognitive decline, SCD (yellow), mild cognitive impairment, MCI (green), Alzheimer’s disease dementia, ADD (blue). Below diagonal: visualization of correlation graphs per variable combination. Diagonal: depiction of variable distribution. Above diagonal: correlation coefficients for (from top to bottom): total dataset (Corr), HC, SCD subjects, MCI patients, and ADD patients. *p < 0.05, **p < 0.01, ***p < 0.001