. 2024 May 24;43:103621. doi: 10.1016/j.nicl.2024.103621

Table 2.

Combined associations of physical activity and sleep parameters with resting-state functional network connectivity and amyloid burden.

		Model 1 Minimally adjusted				Model 2 Fully adjusted
rs-fMRI / PET Measure	Actigraphy Measure	Estimate	SE	p-value	R²_adj	Estimate	SE	p-value	R²_adj

Modularity	TVPA	0.018	0.004	<0.001	0.247	0.012	0.004	0.006**	0.299
	TST	−0.011	0.005	0.013*		−0.010	0.004	0.027*
	Sleep Efficiency	0.014	0.005	0.002**		0.014	0.004	0.002*

Default Mode Connectivity	TVPA	0.019	0.005	<0.001**	0.181	0.017	0.005	0.001***	0.176
	TST	−0.006	0.005	0.207		−0.006	0.005	0.215
	Sleep Efficiency	0.008	0.005	0.090		0.007	0.005	0.163

Salience Ventral Attention Connectivity	TVPA	0.012	0.006	0.037	0.111	0.005	0.006	0.381	0.221
	TST	−0.015	0.006	0.015*		−0.011	0.006	0.053
	Sleep Efficiency	0.020	0.006	0.001**		0.019	0.006	0.001**

Frontoparietal Network Connectivity	TVPA	<-0.001	0.006	0.957	0.009	−0.003	0.006	0.639	0.118
	TST	−0.004	0.005	0.512		−0.002	0.006	0.764
	Sleep Efficiency	0.002	0.005	0.752		0.002	0.006	0.674

PET Amyloid Positive	TVPA	0.030	0.201	0.881	0.015	0.321	0.251	0.200	0.106
	TST	−0.253	0.219	0.248		−0.485	0.256	0.650
	Sleep Efficiency	−0.009	0.215	0.966		0.116	0.262	0.064

Note. TVPA = Total volume of physical activity. SE = Standard Error. TST = Total Sleep Time. PET = Amyloid Positron Emission Tomography Status. Both multiple linear and logistic regressions controlled for age, sex, education, and diagnosis in Model 1 and additionally PiB-PET positive status, vascular risk summary score, and APOE ε4 status in Model 2 (excluding PiB-PET status in the logistic regression for cortical Amyloid PET burden). * p-value < 0.05; ** p-value < 0.01, *** p-value < 0.001. Statistical significance was set based on a two-tailed alpha < 0.05 and Bonferroni family wise error rate (FWER) correction for multiple comparisons of within individual network connectivity analysis. R²_adj = adjusted R-squared model values.