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. 2024 May 31;12:1385712. doi: 10.3389/fcell.2024.1385712

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Copyright © 2024 Calligaris, Zito, Busà, Bulati, Iannolo, Gallo, Carreca, Cuscino, Castelbuono, Carcione, Centi, Amico, Bertani, Chinnici, Conaldi, Scilabra and Miceli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein secretion profiles in conditioned medium (CM) derived from unprimed hAMSCs (ctrl) and primed hAMSCs under hypoxia (HYP) or IFN-γ. (A) Secretion clusters (z-scores) of both up- and downregulated proteins in CM derived from hAMSCs (CM), hypoxic hAMSCs (HYP CM) and IFN-γ-treated hAMSCs (IFN-γ CM). (B) Principal component analysis (PCA). (C) Volcano plot analysis (fold change >1.5 and p < 0.05) of secreted proteins in HYP CM vs. ctrl CM and (D) IFN-γ CM vs. ctrl CM. (E) Venn diagram showing the number of upregulated proteins in HYP CM and IFN-γ CM. (F) Number of GO-enriched terms associated with upregulated HYP CM and (G) IFN-γ CM proteins grouped by category. (H) GO enrichment terms of HYP CM- and (I) IFN-γ CM-upregulated proteins; partial list of the 30 most significantly enriched terms.