FIGURE 8.

Schematic representation of the molecular effects and therapeutic potential of hAMSCs after priming. HAMSCs were preconditioned through hypoxia or IFN-γ treatment and each priming strategy differentially induced the production of specific factors (soluble factors or EXO-containing factors), which affected the activation of biological processes involved in angiogenesis, tissue repair/regeneration and the modulation of inflammation. Additionally, the priming strategies mentioned above also led to the preconditioning of hAMSCs, which in turn influenced the production of functional factors by peripheral blood cells (as shown in the whole blood assay results). Different priming strategies might be used to direct the therapeutic effects of hAMSCs toward specific diseases.