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. 2024 May 8;65(6):100558. doi: 10.1016/j.jlr.2024.100558

Fig. 3.

Fig. 3

Activation of stress response pathways. NanoString pathway score of genes involved in NF-κB pathway signaling (A) and reactive oxygen response (B). mRNA expression (NanoString counts) of genes associated with antioxidant response: Sod1 (C), Sod2 (D), Cat (E), Gpx1 (F), and Tfam (G). mRNA expression (real-time qPCR) of ER stress and UPR markers: Atf4 (H) and Chop (I), Edem (J) and Grp94 (K). Data are presented as mean ± SEM (n ≥ 6). ∗P < 0.05 versus chow, #P < 0.05 versus WD. NanoString mRNA data are reported as counts and real-time qPCR data are reported as relative expression. Atf4, activating transcription factor 4; Cat, catalase; Chop, C/EBP homologous protein; Edem, ER degradation enhancing α-mannosidase like protein 1; ER, endoplasmic reticulum; Gpx1, glutathione peroxidase 1; Grp94, heat shock protein 90 kDa β family member 1; qPCR, quantitative PCR; Sod, superoxide dismutase; Tfam, mitochondrial transcription factor A; UPR, unfolded protein response; WD, Western diet.