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Fatty acid ratios and expression of lipid biosynthetic genes. Total lipids ω-6 to ω-3 PUFA ratio (A), desaturation index (B), and elongation index (C). mRNA expression of genes associated with fatty acid synthesis: Srebp1c (D), Fasn (E) and Scd1 (F). Data are presented as mean ± SEM (n ≥ 6). ∗P < 0.05 versus chow, #P < 0.05 versus WD. Fasn, fatty acid synthase; Scd1, stearoyl-CoA desaturase 1; Srebp1c, sterol regulatory element binding protein 1c; WD, Western diet.
