TABLE 1.
Summary of continuous covariates at baseline and exposure measures for patients included in population pharmacokinetics and exposure–response analyses (N = 429).
| Covariate, units | Mean (SD) | Median (range) |
|---|---|---|
| Weight, kg | 75.8 (20.0) | 74.2 (38.4–228.0) |
| Age, years | 62.9 (11.4) | 65.0 (19.0–80.0) |
| Lactate dehydrogenase, μ/L | 424.0 (421.0) | 297.0 (4.2–4820.0) |
| Albumin, g/L | 36.8 (6.07) | 37.0 (17.1–54.2) |
| Hemoglobin, g/L | 121.0 (19.0) | 123.0 (65.0–170.0) |
| Platelet count, 109/L | 286.0 (121.0) | 259.0 (25.0–881.0) |
| Neutrophil count, 109/L | 6.1 (3.4) | 5.3 (0.46–25.4) |
| B‐cell count, 109/L | 242 (1030) | 90.5 (0–19,100) |
| Log B‐cell count 109/L | 4.4 (1.3) | 4.5 (0–9.9) |
| Neutrophil to lymphocyte ratio | 6.8 (8.1) | 4.3 (0.3–84.7) |
| Tumor size, mm2 | 7420 (12,800) | 4680 (96–227,000) |
| acMMAE C6 AUC, ng*day/mL | 2550 (361) | 2530 (1690–4510) |
| acMMAE C6 C max, ng/mL | 636 (96) | 632 (419–1010) |
| Unconjugated MMAE C6 AUC, ng*day/mL | 15.5 (8.2) | 13.7 (4.1–72.4) |
| Unconjugated MMAE C6 C max, ng/mL | 1.4 (0.6) | 1.3 (0.4–5.4) |
Note: Missing values were replaced by the medians of non‐missing values if missing values were <15%.
Abbreviations: ac, antibody‐conjugated; AUC, area under the concentration–time curve; C, cycle; C max, maximum concentration; MMAE, monomethyl auristatin E; SD, standard deviation.