Table 1.
Baseline Characteristics of 11 653 Patients With Adult Congenital Heart Disease by Arrhythmia at Baseline
| Baseline arrhythmia | |||||
|---|---|---|---|---|---|
| None | Tachyarrhythmia | Conduction disturbances | Both | P value | |
| N | N=10 527 | N=957 | N=109 | N=60 | |
| Age, y, median (IQR) | 45 (30–61) | 61 (47–73) | 50 (34–64) | 64 (49–77) | <0.0001 |
| Number of heart defects, N (%) | |||||
| 1 | 8845 (84.0) | 749 (78.3) | 71 (65.1) | 46 (76.7) | <0.0001 |
| 2 | 1389 (13.2) | 150 (15.7) | 27 (24.8) | 11 (18.3) | |
| 3+ | 293 (2.8) | 58 (6.1) | 11 (10.1) | 3 (5.0) | |
| Other congenital anomaly, N (%) | |||||
| 0 | 9893 (94.0) | 848 (88.6) | 100 (91.7) | 52 (86.7) | <0.0001 |
| 1 | 595 (5.7) | 97 (10.1) | 8 (7.3) | 7 (11.7) | |
| 2+ | 39 (0.4) | 12 (1.3) | 1 (0.9) | 1 (1.7) | |
| Defect complexity, N (%) | |||||
| Simple | 7856 (74.6) | 680 (71.1) | 62 (56.9) | 39 (65.0) | <0.0001 |
| Intermediate | 2193 (20.8) | 215 (22.5) | 38 (34.9) | 11 (18.3) | |
| Complex | 478 (4.5) | 62 (6.5) | 9 (8.3) | 10 (16.7) | |
| Heart defect type, N (%) | |||||
| Patent ductus arteriosus | 513 (4.9) | 27 (2.8) | 4 (3.7) | 3 (5.0) | 0.036 |
| Aortic valve stenosis/insufficiency | 2799 (26.6) | 193 (20.2) | 29 (26.6) | 11 (18.3) | 0.0001 |
| Transposition of great arteries | 67 (0.6) | 6 (0.6) | 4 (3.7) | 0 (0.0) | 0.0014 |
| Atrial septal defect | 3186 (30.3) | 306 (32.0) | 34 (31.2) | 13 (21.7) | 0.3 |
| Mitral valve anomaly | 855 (8.1) | 213 (22.3) | 11 (10.1) | 11 (18.3) | <0.0001 |
| Pulmonary valve anomaly | 377 (3.6) | 25 (2.6) | 9 (8.3) | 4 (6.7) | 0.01 |
| Ebstein anomaly of tricuspid valve | 133 (1.3) | 11 (1.1) | 1 (0.9) | 1 (1.7) | 0.96 |
| Tetralogy of Fallot | 352 (3.3) | 20 (2.1) | 8 (7.3) | 5 (8.3) | 0.002 |
| Ventricular septal defect | 1551 (14.7) | 81 (8.5) | 14 (12.8) | 8 (13.3) | <0.0001 |
| Endocardial cushion | 608 (5.8) | 137 (14.3) | 21 (19.3) | 9 (15.0) | <0.0001 |
| Anomalies of the aorta | 849 (8.1) | 78 (8.2) | 10 (9.2) | 0 (0.0) | 0.14 |
| Other anomaly | 1102 (10.5) | 90 (9.4) | 12 (11.0) | 5 (8.3) | 0.7 |
| Single/common ventricle | 147 (1.4) | 44 (4.6) | 3 (2.8) | 7 (11.7) | <0.0001 |
| Comorbidities, N (%)* | |||||
| Malignancy | 198 (2.0) | 70 (4.8) | 6 (5.1) | 5 (5.6) | <0.0001 |
| Diabetes | 442 (4.4) | 159 (11.2) | 14 (11.8) | 7 (7.1) | <0.0001 |
| Hypertension | 1487 (14.6) | 516 (38.7) | 38 (32.1) | 41 (51.7) | <0.0001 |
| Dyslipidemia | 1408 (13.8) | 419 (31.8) | 36 (30.4) | 32 (50.0) | <0.0001 |
| Ischemic heart disease | 504 (5.0) | 265 (18.8) | 15 (12.8) | 23 (28.9) | <0.0001 |
| Heart failure | 180 (1.8) | 150 (11.2) | 7 (6.0) | 15 (30.5) | <0.0001 |
| Other heart disease† | 432 (4.2) | 225 (18.2) | 97 (89.8) | 52 (92.8) | <0.0001 |
| Stroke/TIA | 432 (4.2) | 167 (12.8) | 5 (4.3) | 11 (10.2) | <0.0001 |
| Charlson comorbidity score, median (IQR) | 0 (0–1) | 3 (1–5) | 2 (0–3) | 4 (1–7) | <0.0001 |
IQR indicates interquartile range; and TIA, transient ischemic attack.
*
Age‐adjusted percentage.
†
Excluding arrhythmia.