A, Patients evaluated at the time of STEMI were found to be indistinguishable with respect to direct hemodynamic measurements. B, Patients were furthermore indistinguishable with regard to Mayo Clinic risk score for prediction of major adverse cardiac events following PCI as well as with (C) the GRACE (Global Registry of Acute Coronary Events) Score. D, At 1‐year follow‐up, patients were distinguished as vulnerable vs resilient on the basis of survival or ≥20% drop in LVEF following MI. The surviving vulnerable cohort demonstrated an LVEF reduction of 24.9% (±5.9%) compared with a 0.9% (±1.9%; P<0.01) drop in the resilient group. Data are reported as mean±SD. Asterisks indicate statistical significance. EDV indicates end‐diastolic volume; ESV, end‐systolic volume; HR, heart rate; LVEF, left ventricular ejection fraction; LVEDP, left ventricular end‐diastolic pressure; LVSP, left ventricular systolic pressure; MACE, major adverse cardiac event; PCI, percutaneous coronary intervention; and STEMI, ST‐segment–elevation myocardial infarction.