Table 2.
Urinary Biomarkers Associated With DHFA With and Without Adjustment
| Uniprot ID | Short name | Nonadjusted | Adjusted | ||||||
|---|---|---|---|---|---|---|---|---|---|
| β | HR | 95% CI | P value | β | HR | 95% CI | P value | ||
| Q9UKU9 | ANGPTL2 | −0.54 | 0.57 | 0.48–0.71 | 7.54E‐08 | −0.56 | 0.57 | 0.47–0.7 | 3.13E0‐5 |
| P04746 | AMY2A | −0.58 | 0.56 | 0.46–0.69 | 2.34E‐08 | −0.6 | 0.55 | 0.44–0.69 | 0.0001 |
| P24855 | DNASE1 | −0.57 | 0.58 | 0.46–0.69 | 2.09E‐08 | −0.56 | 0.57 | 0.46–0.71 | 0.0002 |
| P00352 | ALDH1A1 | −0.52 | 0.60 | 0.49–0.73 | 0.0001 | −0.54 | 0.56 | 0.47–0.72 | 0.0003 |
| P19961 | AMY2B | −0.52 | 0.59 | 0.48–0.73 | 0.0002 | −0.58 | 0.58 | 0.44–0.7 | 0.0003 |
| P00749 | PLAU | −0.52 | 0.60 | 0.49–0.73 | 0.0002 | −0.53 | 0.59 | 0.47–0.74 | 0.0016 |
| P10809 | HSP60 | −0.51 | 0.60 | 0.49–0.74 | 0.0002 | −0.48 | 0.62 | 0.5–0.76 | 0.0017 |
| A0A0C4DGN4 | ZG16B | −0.51 | 0.59 | 0.49–0.73 | 0.0001 | −0.49 | 0.61 | 0.5–0.76 | 0.0018 |
| K4DIA0 | ICOSLG | −0.49 | 0.61 | 0.5–0.74 | 0.0002 | −0.46 | 0.63 | 0.51–0.78 | 0.0067 |
| P00558 | PGKA | −0.42 | 0.66 | 0.54–0.79 | 0.004 | −0.43 | 0.65 | 0.53–0.8 | 0.0101 |
| P01133 | EGF | −0.55 | 0.58 | 0.47–0.71 | 1.33E‐07 | −0.49 | 0.61 | 0.49–0.77 | 0.0102 |
| Q9H0W9 | C11orf54 | −0.4 | 0.67 | 0.55–0.82 | 0.0274 | −0.48 | 0.62 | 0.49–0.78 | 0.0146 |
| K7EPZ6 | MBD1 | 0.42 | 1.52 | 1.23–1.88 | 0.0317 | 0.45 | 1.58 | 1.26–1.96 | 0.0172 |
| A0A075B6N7 | IGHA2 | 0.38 | 1.46 | 1.2–1.77 | 0.045 | 0.4 | 1.50 | 1.23–1.83 | 0.0218 |
| P22732 | SLC2A5 | −0.49 | 0.61 | 0.5–0.75 | 0.0004 | −0.42 | 0.66 | 0.53–0.81 | 0.0286 |
| P25705 | ATP5F1A | −0.45 | 0.64 | 0.52–0.78 | 0.005 | −0.42 | 0.65 | 0.53–0.81 | 0.0309 |
| P05026 | ATP1B1 | −0.45 | 0.64 | 0.52–0.78 | 0.0025 | −0.42 | 0.66 | 0.53–0.81 | 0.0367 |
| Q16651 | Prostasin | −0.45 | 0.64 | 0.52–0.78 | 0.003 | −0.43 | 0.65 | 0.52–0.81 | 0.0372 |
| A0A087X0S5 | COL6A1 | −0.45 | 0.64 | 0.52–0.78 | 0.0031 | −0.43 | 0.65 | 0.52–0.81 | 0.0486 |
| X6R868 | X6R868 | −0.45 | 0.64 | 0.53–0.78 | 0.0019 | −0.42 | 0.66 | 0.53–0.82 | 0.0488 |
| P15291 | B4GALT1 | −0.5 | 0.60 | 0.49–0.74 | 0.0003 | −0.41 | 0.66 | 0.53–0.82 | 0.0499 |
| P02743 | APCS | 0.44 | 1.55 | 1.27–1.88 | 0.0044 | 0.37 | 1.44 | 1.19–1.75 | 0.0552 |
| A0A087X0K0 | COL15A1 | −0.45 | 0.64 | 0.53–0.77 | 0.0014 | −0.4 | 0.67 | 0.55–0.83 | 0.0677 |
| P02768 | Albumin | 0.4 | 1.50 | 1.23–1.82 | 0.0196 | 0.39 | 1.47 | 1.19–1.82 | 0.0967 |
| P33908 | MAN1A1 | −0.44 | 0.65 | 0.53–0.79 | 0.0045 | −0.4 | 0.67 | 0.53–0.84 | 0.1303 |
| Q16769 | QPCT | −0.44 | 0.64 | 0.53–0.78 | 0.0027 | −0.38 | 0.68 | 0.55–0.85 | 0.1414 |
| P01717 | IGLV3‐25 | 0.45 | 1.58 | 1.28–1.94 | 0.0065 | 0.37 | 1.45 | 1.18–1.79 | 0.1528 |
| P43358 | MAGEA4 | 0.37 | 1.45 | 1.2–1.75 | 0.0436 | 0.34 | 1.40 | 1.16–1.7 | 0.1668 |
| Q96RW7 | HMCN1 | −0.39 | 0.68 | 0.55–0.82 | 0.0338 | −0.36 | 0.70 | 0.56–0.86 | 0.2185 |
| J3KPF9 | KIF3A | 0.35 | 1.42 | 1.18–1.69 | 0.0476 | 0.33 | 1.39 | 1.15–1.69 | 0.2265 |
| O75882 | Attractin | −0.38 | 0.68 | 0.56–0.83 | 0.0455 | −0.37 | 0.69 | 0.55–0.86 | 0.2313 |
| P35858 | IGFALS | −0.42 | 0.66 | 0.54–0.81 | 0.0186 | −0.36 | 0.70 | 0.56–0.87 | 0.2734 |
| P16870 | CPE | −0.4 | 0.67 | 0.55–0.82 | 0.0217 | −0.36 | 0.70 | 0.56–0.87 | 0.3026 |
| Q9H756 | LRRC19 | −0.41 | 0.66 | 0.54–0.81 | 0.0131 | −0.35 | 0.70 | 0.56–0.88 | 0.4487 |
| P08582 | MELTF | −0.41 | 0.66 | 0.54–0.81 | 0.0125 | −0.33 | 0.72 | 0.58–0.89 | 0.4703 |
| P00738 | Haptoglobin | 0.4 | 1.50 | 1.22–1.83 | 0.0363 | 0.33 | 1.39 | 1.12–1.71 | 0.5238 |
| P55017 | SLC12A3 | −0.39 | 0.68 | 0.56–0.82 | 0.0307 | −0.32 | 0.73 | 0.6–0.89 | 0.5271 |
| P22891 | PROZ | −0.4 | 0.67 | 0.55–0.81 | 0.0149 | −0.31 | 0.74 | 0.6–0.9 | 0.6072 |
| P05154 | SERPINA5 | −0.4 | 0.67 | 0.55–0.82 | 0.0341 | −0.3 | 0.74 | 0.6–0.92 | 0.8695 |
| O43895 | XPNPEP2 | −0.39 | 0.68 | 0.55–0.83 | 0.04 | −0.28 | 0.76 | 0.61–0.94 | 0.983 |
Urinary proteins significantly associated with the outcome either in unadjusted analyses (left) or analyses that adjusted for urine creatinine levels and the MAGGIC risk score (right). HR indicates hazard ratio; and ID, identification.
ALDH1A1 indicates Aldehyde dehydrogenase 1A1; AMY2A, Pancreatic alpha‐amylase; AMY2B, Pancreatic alpha‐amylase 2B; ANGPTL2, Angiopoietin‐related protein 2; APCS, Serum amyloid P‐component; ATP1B1, Sodium/potassium‐transporting ATPase subunit beta‐1; ATP5F1A, ATP synthase subunit alpha, mitochondrial; B4GALT1, Beta‐1,4‐galactosyltransferase 1; C11orf54, Ester hydrolase C11orf54; COL15A1, Collagen alpha‐1(XV) chain; COL6A1, Collagen alpha‐1(VI) chain; CPE, Carboxypeptidase E; DNASE1, Deoxyribonuclease‐1; EGF, Pro‐epidermal growth factor; HMCN1, Hemicentin‐1; HSPD1, 60 kDa heat shock protein, mitochondrial; ICOSLG, ICOS ligand; IGFALS, Insulin‐like growth factor‐binding protein complex acid labile subunit; IGHA2, Immunoglobulin heavy constant alpha 2 (IGHA2); IGLV3‐25, Immunoglobulin lambda variable 3‐25; KIF3A, Kinesin‐like protein; LRRC19, Leucine‐rich repeat‐containing protein 19; MAGEA4, Melanoma‐associated antigen 4; MAN1A1, Mannosyl‐oligosaccharide 1,2‐alpha‐mannosidase IA; MBD1, Methyl‐CpG‐binding domain protein 1; MELTF, Melanotransferrin; PGKA, Phosphoglycerate kinase 1; PLAU, Urokinase‐type plasminogen activator; PROZ, Vitamin K‐dependent protein Z; QPCT, Glutaminyl‐peptide cyclotransferase; SERPINA5, Plasma serine protease inhibitor; SLC12A3, Solute carrier family 12 member 3; SLC2A5, Solute carrier family 2, facilitated glucose transporter member 5; X6R868, Bile salt activated lipase; XPNPEP2, Xaa‐Pro aminopeptidase 2; and ZG16B, Zymogen granule protein 16 homolog B.